How We Approach Smoldering Multiple Myeloma
نویسندگان
چکیده
منابع مشابه
How I treat smoldering multiple myeloma.
Smoldering myeloma is a heterogeneous clinical entity where a subset of patients has an indolent course of disease that mimics monoclonal gammopathy of undermined significance, whereas others have a more aggressive course that has been described as "early myeloma." It is defined as either serum M-protein ≥ 3 g/L or ≥ 10% monoclonal plasma cells in the bone marrow. There are currently no molecul...
متن کاملHow I Treat How I treat smoldering multiple myeloma
Although the last decade has seen the development of effective targeted therapies for patients with multiple myeloma (MM), the clinical utility of targeted therapies has been hampered by the development of drug resistance, clonal evolution, and disease progression, making the quest for cure ever more elusive for MM. However, one may argue that the concept of initiating therapy at the time of sy...
متن کاملSmoldering Multiple Myeloma
Smoldering multiple myeloma (SMM) is an asymptomatic precursor stage of multiple myeloma (MM) characterized by clonal bone marrow plasma cells (BMPC) ≥ 10% and/or M protein level ≥ 30 g/L in the absence of end organ damage. It represents an intermediate stage between monoclonal gammopathy of undetermined significance (MGUS) and symptomatic MM. The risk of progression to symptomatic MM is not un...
متن کامل[Smoldering multiple myeloma].
Smoldering multiple myeloma (SMM) is an asymptomatic plasma cell neoplasia, characterized by monoclonal plasma cell proliferation in the absence of end-organ damage, but with a high risk of progression to multiple myeloma. It has therefore to be distinguished from monoclonal gammapathy of undetermined significance (MGUS), which has a much lower risk of progression, but also from multiple myelom...
متن کاملV. Smoldering multiple myeloma.
Smoldering multiple myeloma (SMM) is an asymptomatic plasma cell disorder defined in 1980 by Kyle and Greipp on the basis of a series of six patients who met the criteria for multiple myeloma (MM) but whose disease did not have an aggressive course [1]. At the end of 2014, the International Myeloma Working Group (IMWG) updated the definition, and SMM is now defined as a plasma cell disorder cha...
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ژورنال
عنوان ژورنال: Journal of Clinical Oncology
سال: 2020
ISSN: 0732-183X,1527-7755
DOI: 10.1200/jco.19.02834